August 7, 2020
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Detecting the H3F3A mutant allele found in high-grade pediatric glioma by real-time PCR.
Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brain tumors with a median survival of 1 year after diagnosis. It has been reported recently that about 80% of cases DIPG and 70% of glioblastomas middle line contained a mutation in one allele of the gene H3F3A (encoding the H3 histone variant H3.3), replacing the lysine 27 to methionine (K27M). In order to facilitate the […]