Molecular analysis of the t(2;8)/MYC-IGK translocation in high-grade lymphoma/leukemia by long-distance inverse PCR.
Burkitt’s lymphoma and a subset of diffuse large B-cell lymphoma that is characterized by chromosomal changes affecting the MYC oncogene at 8q24. In most cases the MYC was found juxtaposed with the immunoglobulin heavy chain (IGH) gene locus. Translocation to the immunoglobulin kappa locus (IGK) gene on the 2p11 were observed in approximately 5-10% of cases. few data exist on the molecular mechanisms that lead […]